KEGG   REACTION: R06458
Entry
R06458                      Reaction                               
Name
(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide forming)
Definition
5 (S)-Methylmalonyl-CoA + Malonyl-CoA + 5 NADPH + 5 H+ <=> 10-Deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O
Equation
5 C00683 + C00083 + 5 C00005 + 5 C00080 <=> C11993 + 6 C00010 + 6 C00011 + 5 C00006 + 2 C00001
Comment
type I polyketide synthase,PikA1-3
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00683
RC02829  C00683_C11993
RC02830  C00683_C11993
RC02831  C00683_C11993
RC02910  C00683_C11993
RC02911  C00083_C11993
RC02915  C00683_C11993
Enzyme
2.3.1.239
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.239
     R06458  5 (S)-Methylmalonyl-CoA + Malonyl-CoA + 5 NADPH + 5 H+ <=> 10-Deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O
Orthology
K16000  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16001  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
K16002  narbonolide/10-deoxymethynolide synthase [EC:2.3.1.240 2.3.1.239]
Other DBs
RHEA: 43059

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (9)   
   KEGG ENZYME (1)   
   KEGG RCLASS (8)   
Gene (6)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (3)   
All databases (32)   

Download RDF
DBGET integrated database retrieval system